Director, Drug Safety & Pharmacovigilance

June 3, 2026

Introduction:<p style="text-align: justify; background: white; margin: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;" data-mce-style="text-align: justify; background: white; margin: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;"><span style="font-size: 11.0pt; font-family: Calibri, sans-serif; color: #222222; border: none windowtext 1.0pt; padding: 0in;" data-mce-style="font-size: 11.0pt; font-family: Calibri, sans-serif; color: #222222; border: none windowtext 1.0pt; padding: 0in;">Xencor is a public, clinical-stage biopharmaceutical company located in the Los Angeles area (Pasadena) and in San Diego. Our focus is developing high-potential XmAb® bispecific T-cell engagers and additional engineered drug candidates that leverage our differentiated technology platforms, and we are advancing our pipeline toward clinical proof-of-concept decisions. Our goal is to create high-impact therapeutics for patients with cancer and other serious diseases. More than 20 XmAb drug candidates engineered with our technology are in clinical development, and three XmAb medicines have been marketed by partners. For more information, please visit www.xencor.com. We have an excellent opportunity for a Director, Drug Safety & Pharmacovigilance, to join our team.<p style="text-align: justify; background: white; margin: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;" data-mce-style="text-align: justify; background: white; margin: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;"> <p style="text-align: justify; background: white; margin: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;" data-mce-style="text-align: justify; background: white; margin: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;"><span style="font-size: 11.0pt; font-family: Calibri, sans-serif; color: #222222; border: none windowtext 1.0pt; padding: 0in;" data-mce-style="font-size: 11.0pt; font-family: Calibri, sans-serif; color: #222222; border: none windowtext 1.0pt; padding: 0in;">This position will be based in San Diego, CA. and have 2 days a week hybrid on-site. Potentially for fully remote if not local to San Diego.<p style="text-align: justify; background: white; margin: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;" data-mce-style="text-align: justify; background: white; margin: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;"> Summary: Responsible for all aspects of safety related to Drug Safety & Pharmacovigilance (PV) processes and the analytical assessment of safety data for assigned product(s). Primary Responsibilities:<ul style="margin-top: 0in; margin-bottom: 0in;" type="disc" data-mce-style="margin-top: 0in; margin-bottom: 0in;"><li style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;" data-mce-style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;">Provides day-to-day oversight of safety monitoring activities and processes for assigned product(s)</li><li style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;" data-mce-style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;">Works collaboratively with the Medical Monitor/Clinical Scientist on ICSRs, aggregate data review/signaling, and core risk language for assigned product(s). </li><li style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;" data-mce-style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;">Provides clinical review of vendor’s narratives for quality and completeness and ensures timely submission of expedited reports. Contributes to the creation of analysis of similar events. </li><li style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;" data-mce-style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;">Facilitates and leads cross-functional safety data review and signaling meetings; includes setting agenda, coordinating materials, data presentation, and documentation. </li><li style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;" data-mce-style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;">Reviews and provides safety functional input for development of protocols, IBs, ICFs, CSRs and other relevant study documents</li><li style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;" data-mce-style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;">Acts as lead author for aggregate safety reports (e.g., DSURs)</li><li style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;" data-mce-style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;">Leads efforts related to ad hoc and routine signal evaluation </li><li style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;" data-mce-style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;">Provides Drug Safety/PV subject matter expertise on cross-functional platforms and teams throughout the company</li><li style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;" data-mce-style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;">Provides end to end Drug Safety/PV support for assigned products including study start up activities, vendor plans, signal detection plans, SAE review, aggregate data review, signaling, aggregate authoring including DSURs, annual core product document updates (IB, ICF), and CSR authoring as well as informed consent forms, integrated summaries of safety, marketing applications and other regulatory submission documents on assigned products. </li><li style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;" data-mce-style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;">Collaborates with partners on safety monitoring, signal detection and risk management activities. </li><li style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;" data-mce-style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;">Participates in establishing and maintaining Safety Data Exchange Agreements/Pharmacovigilance Agreements. </li><li style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;" data-mce-style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;">Ensures adherence to GCP/ICH and SOP standards</li><li style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;" data-mce-style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;">Participates in inspection readiness activities and preparation. </li><li style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;" data-mce-style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;">Ensures that the above tasks are performed in the most efficient manner possible, commensurate with quality, accuracy, and timeliness and in accordance with current global regulatory requirements</li><li style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;" data-mce-style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;">Ensures that all activities/reviews are compliant with the latest safety standards and regulations</li><li style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;" data-mce-style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;">Adheres to all department and company-wide policies regarding conduct, performance and procedures</li><li style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;" data-mce-style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;">Provides oversight and direction to direct and indirect reports, as applicable, in accordance with the organization’s policies and procedures. The responsibilities may include, but are not limited to recruiting, training, communicating job expectations, appraising and managing job performance, delivering feedback and coaching, and providing career development planning and opportunities</li><li style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;" data-mce-style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;">Performs other duties as assigned. </li></ul>Education/Experience/Skills: Required - Advanced nursing degree or PharmDAt least 8 years drug safety experienceAt least 5 years managing medical case review and signal detection At least 4 years of clinical experience Preferred -MD Experience in a critical care settingExperience in oncology and/or autoimmune drug development Position also requires:<ul style="margin-top: 0in; margin-bottom: 0in;" type="disc" data-mce-style="margin-top: 0in; margin-bottom: 0in;"><li style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;" data-mce-style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;">Solid experience with work such as signaling, aggregate report authoring and experience reviewing cumulative safety data with ability to interpret, synthesize and communicate complex clinical information. </li><li style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;" data-mce-style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;">Strong knowledge and understanding of international safety reporting and pharmacovigilance requirements and signal detection</li><li style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;" data-mce-style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;">Ability to take initiative yet work collaboratively on multiple projects and with partner companies to achieve goals in compliance with PV and regulatory requirements and safety data exchange and/or pharmacovigilance agreements</li><li style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;" data-mce-style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;">Excellent written and oral communication skills</li><li style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;" data-mce-style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;">Excellent interpersonal skills and ability to work effectively as part of a team(s)</li><li style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;" data-mce-style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;">Knowledge of pharmacovigilance and ability to apply knowledge to the evaluation of safety concerns and minimization of patient risk throughout the life cycle of drug products. </li><li style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;" data-mce-style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;">Thorough understanding of the drug development process in relation to safety surveillance activities in clinical trials</li><li style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;" data-mce-style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;">Ability to establish effective working relationships with people in a wide variety of disciplines and backgrounds</li><li style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;" data-mce-style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;">Ability to manage and prioritize multiple projects and demands simultaneously, rapidly adjust to changing priorities, and work effectively under pressure</li><li style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;" data-mce-style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;">Knowledge and understanding of all relevant global PV regulations, FDA, EU and ICH guidelines, initiatives and regulations governing clinical trial safety environments</li><li style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;" data-mce-style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;">Familiarity with Argus safety database</li><li style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;" data-mce-style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;">Knowledge and training on MedDRA dictionary with relevance to adverse event coding</li><li style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;" data-mce-style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;">Excellent interpersonal skills and professionalism</li><li style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;" data-mce-style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;">Excellent time management and organizational skills</li><li style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;" data-mce-style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;">Strong analytical, assessment and problem-solving skills</li><li style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;" data-mce-style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;">Ability to read, analyze and interpret complex clinical data and information</li><li style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;" data-mce-style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;">Ability to demonstrate competencies applicable for job based on Xencor’s Leadership Competency Model</li><li style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;" data-mce-style="margin-top: 0in; margin-right: 0in; margin-bottom: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;">Ability to effectively manage others through coaching and supervision, in accordance with company policies and practices. Ensures employee performance meets the organization’s expectations for conduct, productivity, quality, continuous improvement, and goal accomplishment.</li></ul> Occasional travel may be required, including travel between Xencor’s Pasadena and San Diego offices. Work for this position is generally performed at Xencor’s worksite and requires full-time commitment. Expected Base Salary Range: $206,000 - $255,000The actual salary will be based on the selected candidate’s qualifications, including skills, competencies, education and experience. Xencor offers a competitive total rewards package including 401k match, healthcare coverage, ESPP and a broad range of other benefits. In addition, this position will be eligible for an annual bonus and equity grant. For more information, please see <a rel="noopener" href="https://xencor.com/careers/" target="_blank" data-mce-href="https://xencor.com/careers/">https://xencor.com/careers/</a>. <span style="font-family: Calibri, sans-serif; color: #222222; border: none windowtext 1.0pt; padding: 0in;" data-mce-style="font-family: Calibri, sans-serif; color: #222222; border: none windowtext 1.0pt; padding: 0in;">Americans with Disabilities Act (ADA) Statement<p style="text-align: justify; background: white; margin: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;" data-mce-style="text-align: justify; background: white; margin: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;"><span style="font-size: 11.0pt; font-family: Calibri, sans-serif; color: #222222; border: none windowtext 1.0pt; padding: 0in;" data-mce-style="font-size: 11.0pt; font-family: Calibri, sans-serif; color: #222222; border: none windowtext 1.0pt; padding: 0in;">The Company will provide reasonable accommodations (such as a qualified sign language interpreter or other personal assistance) with the application process upon your request as required to comply with applicable laws. If you have a disability and require assistance in this application process, please contact HR@xencor.com.<p style="text-align: justify; background: white; margin: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;" data-mce-style="text-align: justify; background: white; margin: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;"><span style="font-size: 11.0pt; font-family: Calibri, sans-serif; color: #222222; border: none windowtext 1.0pt; padding: 0in;" data-mce-style="font-size: 11.0pt; font-family: Calibri, sans-serif; color: #222222; border: none windowtext 1.0pt; padding: 0in;"> <p style="text-align: justify; background: white; margin: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;" data-mce-style="text-align: justify; background: white; margin: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;"><span style="font-size: 11.0pt; font-family: Calibri, sans-serif; color: #222222; border: none windowtext 1.0pt; padding: 0in;" data-mce-style="font-size: 11.0pt; font-family: Calibri, sans-serif; color: #222222; border: none windowtext 1.0pt; padding: 0in;">To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. Reasonable Accommodations may be made to enable qualified individuals with disabilities to perform the essential functions.<span style="font-size: 11.0pt; font-family: Calibri, sans-serif; color: #222222; border: none windowtext 1.0pt; padding: 0in;" data-mce-style="font-size: 11.0pt; font-family: Calibri, sans-serif; color: #222222; border: none windowtext 1.0pt; padding: 0in;"> <span style="font-family: Calibri, sans-serif; color: #222222; border: none windowtext 1.0pt; padding: 0in;" data-mce-style="font-family: Calibri, sans-serif; color: #222222; border: none windowtext 1.0pt; padding: 0in;">Equal Employment Opportunity (EEO) Statement<p style="text-align: justify; background: white; margin: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;" data-mce-style="text-align: justify; background: white; margin: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;"><span style="font-size: 11.0pt; font-family: Calibri, sans-serif; color: #222222; border: none windowtext 1.0pt; padding: 0in;" data-mce-style="font-size: 11.0pt; font-family: Calibri, sans-serif; color: #222222; border: none windowtext 1.0pt; padding: 0in;">The Company is an equal opportunity employer, and all qualified applicants will receive consideration for employment without regard to age, race, color, religion, sex, sexual orientation, gender or gender identity, national origin, disability status, protected veteran status or any other characteristic protected by state or federal law.<p style="text-align: justify; background: white; margin: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;" data-mce-style="text-align: justify; background: white; margin: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;"><span style="font-size: 11.0pt; font-family: Calibri, sans-serif; color: #222222; border: none windowtext 1.0pt; padding: 0in;" data-mce-style="font-size: 11.0pt; font-family: Calibri, sans-serif; color: #222222; border: none windowtext 1.0pt; padding: 0in;"> <p style="text-align: justify; background: white; margin: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;" data-mce-style="text-align: justify; background: white; margin: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;"><span style="font-size: 11.0pt; font-family: Calibri, sans-serif; color: #222222; border: none windowtext 1.0pt; padding: 0in;" data-mce-style="font-size: 11.0pt; font-family: Calibri, sans-serif; color: #222222; border: none windowtext 1.0pt; padding: 0in;">Xencor does not accept profiles or resumes from recruiting vendors without a binding written agreement. Any unsolicited submission of services and or resumes in no way creates an obligation or duty by Xencor, implied or otherwise.<p style="text-align: justify; line-height: 150%; margin: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;" data-mce-style="text-align: justify; line-height: 150%; margin: 0in; font-size: 12pt; font-family: 'TmsRmn 12pt', serif;">

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Director, Drug Safety & Pharmacovigilance

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